Name | Fmoc-isonipecotic acid |
Synonyms | Fmoc-Inp-OH RARECHEM AR PA 0004 Fmoc-isonipecotic acid N-ALPHA-FMOC-PIPERIDINE-4-CARBOXYLIC ACID N-(9-FLUORENYLMETHYLOXYCARBONYL)-ISONIPECOTIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-HEXAHYDROISONICOTINIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID N-(9-FLUORENYLMETHYLOXYCARBONYL)-PIPERIDINE-4-CARBOXYLIC ACID 1-[9H-fluoren-9-ylmethoxy(oxo)methyl]-4-piperidinecarboxylic acid N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-PIPERIDINE-4-CARBOXYLIC ACID |
CAS | 148928-15-8 |
EINECS | 2017-001-1 |
InChI | InChI=1/C21H21NO4/c23-20(24)14-9-11-22(12-10-14)21(25)26-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,14,19H,9-13H2,(H,23,24) |
Molecular Formula | C21H21NO4 |
Molar Mass | 351.4 |
Density | 1.293 |
Melting Point | ~190°C (dec.) |
Boling Point | 561.6±43.0 °C(Predicted) |
Flash Point | 293.5°C |
Vapor Presure | 1.89E-13mmHg at 25°C |
Appearance | Powder |
Color | White |
BRN | 7722550 |
pKa | 4.54±0.20(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.62 |
MDL | MFCD00273475 |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
WGK Germany | 3 |
HS Code | 2933 39 99 |
Hazard Class | IRRITANT |
Use | 1-[(9-H-fluorene-9-methoxy) carbonyl] piperidin-4-carboxylic acid is an important intermediate for the synthesis of piperidine drugs, Has been extensively studied. Piperidine is the most common nitrogen-containing heterocyclic ring, which is widely found in existing drugs and natural products. Alkaloids with piperidine as the mother have various physiological activities and have potential application value in anticancer, antibacterial, antiviral and diabetes treatment. Among the chemical structures of many biologically active natural and non-natural substances, the piperidine ring is a common and important component. Among them, the different 4-position substituted functional groups of piperidine ring can greatly affect the biological activity of the molecule. |
preparation | comprehensive literature reports and experimental design, we used 4-piperidinic acid as the starting material to synthesize 1-[(9-H-fluoren-9-methoxy) carbonyl] piperidin-4-carboxylic acid. |